{"id":1130,"date":"2024-04-11T10:35:41","date_gmt":"2024-04-11T10:35:41","guid":{"rendered":"https:\/\/www.rookon.com\/?p=1130"},"modified":"2024-04-12T09:54:59","modified_gmt":"2024-04-12T09:54:59","slug":"%e0%b8%ab%e0%b8%a5%e0%b8%b1%e0%b8%81%e0%b8%90%e0%b8%b2%e0%b8%b2%e0%b8%99%e0%b8%a7%e0%b9%88%e0%b8%b2%e0%b8%a7%e0%b8%b1%e0%b8%84%e0%b8%8b%e0%b8%b5%e0%b8%99%e0%b9%82%e0%b8%84%e0%b8%a7%e0%b8%b4%e0%b8%94","status":"publish","type":"post","link":"https:\/\/www.rookon.com\/?p=1130","title":{"rendered":"\u0e2b\u0e25\u0e31\u0e01\u0e10\u0e32\u0e19\u0e27\u0e48\u0e32\u0e27\u0e31\u0e04\u0e0b\u0e35\u0e19\u0e42\u0e04\u0e27\u0e34\u0e14\u0e44\u0e21\u0e48\u0e1b\u0e25\u0e2d\u0e14\u0e20\u0e31\u0e22 | \u0e25\u0e49\u0e32\u0e07\u0e1e\u0e34\u0e29\u0e01\u0e31\u0e19\u0e40\u0e16\u0e2d\u0e30"},"content":{"rendered":"\n<p>Youtube.com<\/p>\n\n\n<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/wQ6cMQ9fcWg?si=8KJSC1uoWU9F7uoN\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>Rumble.com<\/p>\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-rumble-com wp-block-embed-rumble-com\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" title=\"\u0e2b\u0e25\u0e31\u0e01\u0e10\u0e32\u0e32\u0e19\u0e27\u0e48\u0e32\u0e27\u0e31\u0e04\u0e0b\u0e35\u0e19\u0e42\u0e04\u0e27\u0e34\u0e14\u0e44\u0e21\u0e48\u0e44\u0e14\u0e49\u0e1b\u0e25\u0e2d\u0e14\u0e20\u0e31\u0e22\" src=\"https:\/\/rumble.com\/embed\/v4m9cjr\/?pub=l04pz#?secret=QUqGpiwRq2\" data-secret=\"QUqGpiwRq2\" width=\"960\" height=\"540\" frameborder=\"0\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li>(2022) \u0e1a\u0e31\u0e19\u0e17\u0e36\u0e01\u0e02\u0e2d\u0e07 FDA \u0e17\u0e35\u0e48\u0e40\u0e01\u0e35\u0e48\u0e22\u0e27\u0e02\u0e49\u0e2d\u0e07\u0e01\u0e31\u0e1a\u0e01\u0e32\u0e23\u0e28\u0e36\u0e01\u0e29\u0e32\u0e17\u0e35\u0e48\u0e44\u0e21\u0e48\u0e43\u0e0a\u0e48\u0e17\u0e32\u0e07\u0e04\u0e25\u0e34\u0e19\u0e34\u0e01\u0e40\u0e01\u0e35\u0e48\u0e22\u0e27\u0e01\u0e31\u0e1a\u0e27\u0e31\u0e04\u0e0b\u0e35\u0e19\u0e1b\u0e49\u0e2d\u0e07\u0e01\u0e31\u0e19\u0e42\u0e04\u0e27\u0e34\u0e14-19 \u0e02\u0e2d\u0e07\u0e44\u0e1f\u0e40\u0e0b\u0e2d\u0e23\u0e4c \u0e0b\u0e36\u0e48\u0e07\u0e40\u0e1c\u0e22\u0e41\u0e1e\u0e23\u0e48\u0e15\u0e32\u0e21\u0e04\u0e33\u0e02\u0e2d\u0e02\u0e2d\u0e07 FOIA (Freedom of Information Act) \u0e1b\u0e35 2021-4389:  <a href=\"https:\/\/archive.org\/details\/Pfizer-vaccine-nonclinical\">https:\/\/archive.org\/details\/Pfizer-vaccine-nonclinical<\/a><\/li>\n\n\n\n<li><em>no traditional pharmacokinetic or biodistribution studies have been performed with the vaccine candidate BNT162b2.<\/em> <br>\u0e44\u0e21\u0e48\u0e21\u0e35\u0e01\u0e32\u0e23\u0e28\u0e36\u0e01\u0e29\u0e32\u0e40\u0e20\u0e2a\u0e31\u0e0a\u0e08\u0e25\u0e19\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e2b\u0e23\u0e37\u0e2d\u0e01\u0e32\u0e23\u0e01\u0e23\u0e30\u0e08\u0e32\u0e22\u0e15\u0e31\u0e27\u0e17\u0e32\u0e07\u0e0a\u0e35\u0e27\u0e20\u0e32\u0e1e\u0e41\u0e1a\u0e1a\u0e14\u0e31\u0e49\u0e07\u0e40\u0e14\u0e34\u0e21\u0e01\u0e31\u0e1a\u0e27\u0e31\u0e04\u0e0b\u0e35\u0e19 BNT162b2<br>\u0e2b\u0e19\u0e49\u0e32 45 : <a href=\"https:\/\/www.ema.europa.eu\/en\/documents\/assessment-report\/comirnaty-epar-public-assessment-report_en.pdf\">https:\/\/www.ema.europa.eu\/en\/documents\/assessment-report\/comirnaty-epar-public-assessment-report_en.pdf<\/a><\/li>\n\n\n\n<li>\u0e41\u0e21\u0e49\u0e27\u0e48\u0e32\u0e08\u0e30\u0e21\u0e35\u0e01\u0e32\u0e23\u0e28\u0e36\u0e01\u0e29\u0e32\u0e04\u0e27\u0e32\u0e21\u0e40\u0e1b\u0e47\u0e19\u0e1e\u0e34\u0e29\u0e2d\u0e22\u0e48\u0e32\u0e07\u0e08\u0e33\u0e01\u0e31\u0e14 \u0e41\u0e15\u0e48\u0e01\u0e47\u0e44\u0e21\u0e48\u0e40\u0e04\u0e22\u0e21\u0e35\u0e01\u0e32\u0e23\u0e28\u0e36\u0e01\u0e29\u0e32\u0e40\u0e20\u0e2a\u0e31\u0e0a\u0e08\u0e25\u0e19\u0e28\u0e32\u0e2a\u0e15\u0e23\u0e4c\u0e17\u0e35\u0e48\u0e2a\u0e21\u0e1a\u0e39\u0e23\u0e13\u0e4c\u0e02\u0e2d\u0e07 mRNA \u0e02\u0e2d\u0e07\u0e2a\u0e32\u0e23\u0e2d\u0e2d\u0e01\u0e24\u0e17\u0e18\u0e34\u0e4c\u0e40\u0e25\u0e22!<br><em>Distribution to the liver is likely mediated by LNPs entering the blood stream. The luciferase expression at the injection sites dropped to background levels after 9 days. The repeat-dose toxicity study in rats showed no evidence of liver injury (Section 2.4.4.3).\u00a0<\/em><strong><em>The biodistribution of the antigen encoded by the RNA component of BNT162b2 is expected to be dependent on the LNP distribution and the results presented should be representative for the vaccine RNA platform<\/em><\/strong><em>, as the LNP-formulated luciferase-encoding modRNA had the same lipid composition.<\/em><br>\u0e41\u0e1b\u0e25\u0e44\u0e17\u0e22 : \u0e01\u0e32\u0e23\u0e41\u0e1e\u0e23\u0e48\u0e01\u0e23\u0e30\u0e08\u0e32\u0e22\u0e44\u0e1b\u0e22\u0e31\u0e07\u0e15\u0e31\u0e1a\u0e21\u0e35\u0e41\u0e19\u0e27\u0e42\u0e19\u0e49\u0e21\u0e17\u0e35\u0e48\u0e08\u0e30\u0e40\u0e1b\u0e47\u0e19\u0e2a\u0e37\u0e48\u0e2d\u0e01\u0e25\u0e32\u0e07\u0e42\u0e14\u0e22 LNP \u0e17\u0e35\u0e48\u0e40\u0e02\u0e49\u0e32\u0e2a\u0e39\u0e48\u0e01\u0e23\u0e30\u0e41\u0e2a\u0e40\u0e25\u0e37\u0e2d\u0e14 \u0e01\u0e32\u0e23\u0e41\u0e2a\u0e14\u0e07\u0e2d\u0e2d\u0e01\u0e02\u0e2d\u0e07\u0e25\u0e39\u0e0b\u0e34\u0e40\u0e1f\u0e2d\u0e40\u0e23\u0e2a\u0e17\u0e35\u0e48\u0e1a\u0e23\u0e34\u0e40\u0e27\u0e13\u0e17\u0e35\u0e48\u0e09\u0e35\u0e14\u0e25\u0e14\u0e25\u0e07\u0e2a\u0e39\u0e48\u0e23\u0e30\u0e14\u0e31\u0e1a\u0e1e\u0e37\u0e49\u0e19\u0e2b\u0e25\u0e31\u0e07\u0e2b\u0e25\u0e31\u0e07\u0e08\u0e32\u0e01 9 \u0e27\u0e31\u0e19 \u0e01\u0e32\u0e23\u0e28\u0e36\u0e01\u0e29\u0e32\u0e04\u0e27\u0e32\u0e21\u0e40\u0e1b\u0e47\u0e19\u0e1e\u0e34\u0e29\u0e08\u0e32\u0e01\u0e01\u0e32\u0e23\u0e43\u0e2b\u0e49\u0e22\u0e32\u0e0b\u0e49\u0e33\u0e43\u0e19\u0e2b\u0e19\u0e39\u0e44\u0e21\u0e48\u0e1e\u0e1a\u0e2b\u0e25\u0e31\u0e01\u0e10\u0e32\u0e19\u0e01\u0e32\u0e23\u0e1a\u0e32\u0e14\u0e40\u0e08\u0e47\u0e1a\u0e17\u0e35\u0e48\u0e15\u0e31\u0e1a (\u0e2b\u0e31\u0e27\u0e02\u0e49\u0e2d 2.4.4.3) \u0e01\u0e32\u0e23\u0e01\u0e23\u0e30\u0e08\u0e32\u0e22\u0e15\u0e31\u0e27\u0e17\u0e32\u0e07\u0e0a\u0e35\u0e27\u0e20\u0e32\u0e1e\u0e02\u0e2d\u0e07\u0e41\u0e2d\u0e19\u0e15\u0e34\u0e40\u0e08\u0e19\u0e17\u0e35\u0e48\u0e40\u0e02\u0e49\u0e32\u0e23\u0e2b\u0e31\u0e2a\u0e42\u0e14\u0e22\u0e2a\u0e48\u0e27\u0e19\u0e1b\u0e23\u0e30\u0e01\u0e2d\u0e1a RNA \u0e02\u0e2d\u0e07 BNT162b2 \u0e04\u0e32\u0e14\u0e27\u0e48\u0e32\u0e08\u0e30\u0e02\u0e36\u0e49\u0e19\u0e2d\u0e22\u0e39\u0e48\u0e01\u0e31\u0e1a\u0e01\u0e32\u0e23\u0e01\u0e23\u0e30\u0e08\u0e32\u0e22\u0e02\u0e2d\u0e07 LNP \u0e41\u0e25\u0e30\u0e1c\u0e25\u0e25\u0e31\u0e1e\u0e18\u0e4c\u0e17\u0e35\u0e48\u0e19\u0e33\u0e40\u0e2a\u0e19\u0e2d\u0e04\u0e27\u0e23\u0e40\u0e1b\u0e47\u0e19\u0e15\u0e31\u0e27\u0e41\u0e17\u0e19\u0e2a\u0e33\u0e2b\u0e23\u0e31\u0e1a\u0e41\u0e1e\u0e25\u0e15\u0e1f\u0e2d\u0e23\u0e4c\u0e21 RNA \u0e02\u0e2d\u0e07\u0e27\u0e31\u0e04\u0e0b\u0e35\u0e19 \u0e40\u0e19\u0e37\u0e48\u0e2d\u0e07\u0e08\u0e32\u0e01 modRNA \u0e17\u0e35\u0e48\u0e40\u0e02\u0e49\u0e32\u0e23\u0e2b\u0e31\u0e2a luciferase \u0e17\u0e35\u0e48\u0e2a\u0e23\u0e49\u0e32\u0e07\u0e14\u0e49\u0e27\u0e22\u0e2a\u0e39\u0e15\u0e23 LNP \u0e21\u0e35\u0e2d\u0e07\u0e04\u0e4c\u0e1b\u0e23\u0e30\u0e01\u0e2d\u0e1a\u0e02\u0e2d\u0e07\u0e44\u0e02\u0e21\u0e31\u0e19\u0e40\u0e2b\u0e21\u0e37\u0e2d\u0e19\u0e01\u0e31\u0e19<br>\u0e2b\u0e19\u0e49\u0e32\u0e17\u0e35\u0e48 43 : <a href=\"https:\/\/archive.org\/details\/Pfizer-vaccine-nonclinical \">https:\/\/archive.org\/details\/Pfizer-vaccine-nonclinical <\/a><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n","protected":false},"excerpt":{"rendered":"<p>Youtube.com Rumble.com<\/p>\n","protected":false},"author":1,"featured_media":1133,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":{"0":"post-1130","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-vaccine"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - 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